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International nonproprietary name: enrofloxacin, colistin sulfate.

Enrocolistim contains in 1 ml as an active substance: enrofloxacin - 100 mg and colistin sulfate 2000000 IU, as auxiliary substances: lactic acid - 100 mg, propylene glycol - 100 mg, benzyl alcohol - 14 mg and purified water up to 1 ml.

Enrocolistim is released packaged by 10, 50, 100, 250, 500, 1000, 2500, 5000 ml in glass or plastic vials, capped with screw-on lids with a first opening control ring and provided with instructions for use.

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Bactericidal agent
Dosage form
Solution for oral use
Transparent liquid of light yellow color
1L; 5L
Pharmacological properties

ENROCOLISTIM is a complex antimicrobial drug.

Enrofloxacin, which is part of the drug, is a derivative of quinol carboxylic acid, belongs to the 3rd generation fluoroquinolones, has a wide spectrum of bactericidal action against most gram-negative and gram-positive microorganisms, including Escherichia coli, Pseudomonas aeruginosa, Salmonella spp., Pasteurella spp., Staphylococcus spp., Staphylococcus hyicus, Streptococcu ssp., Klebsiella spp., Bordetella bronchiseptica, Campylobacter spp., Corynebacterium spp., Erysipelothrix spp., Proteus spp., Brucellacanis, Actinobacillus spp., Listeria monocytogenes, Haemophilus spp., Clostridium spp., as well as Mycoplasma spp.

Enrofloxacin suppresses bacterial DNA gyrase, disrupts DNA synthesis, bacterial growth and division; causes pronounced morphological changes (including in the cell wall and membranes), which leads to rapid bacterial cell death.

Colistin sulfate, which is part of the preparation, is polymyxin E, related to cyclic polypeptides. Colistin has a bactericidal effect on gram-negative microorganisms in the stage of division and dormancy by changing the structure and function of the outer and cytoplasmic membrane. The antibiotic is active against Escherichia coli, Salmonella spp., Pseudomonas aeruginosa, Pasteurellas pp., Haemophilus spp., Acinetobacter spp., Citrobacter spp., Klebsiella spp., Shigella spp.

When used together, enrofloxacin and colistin have a mutually reinforcing effect on microorganisms due to a different mechanism of bactericidal action. Resistance to the antibacterial components of the drug develops slowly.

After oral administration of ENROCOLISTIM, enrofloxacin is well absorbed from the gastrointestinal tract, distributed in tissues and maintained at a therapeutic level during the day. Its maximum concentration in the blood plasma is reached 1.5-3 hours after the application of the drug. Enrofloxacin is excreted through the kidneys (about 70%) and with bile (about 30%) both unchanged and in the form of metabolites, the main of which is ciprofloxacin.

Colistin sulfate is not exposed to digestive enzymes, is practically not absorbed, and has its antimicrobial effect directly in the intestine.

The combination of enrofloxacin and colistin sulfate has a potentiating effect against E.coli and P.multocida, and also prevents the rapid development of resistance of microorganisms to fluoroquinolones.

Application procedure
ENROCOLISTIM is used for broiler chickens, breeding poultry, repair young, turkey pigs, calves, lambs, for the treatment and prevention of respiratory and intestinal diseases of bacterial etiology, including colibacteriosis, salmonellosis, streptococcosis, pasteurellosis, hemaphylosis, mycoplasmosis, as well as mixed and secondary infections, the causative agents of which are sensitive enrofloxacin and its combination with colistin.

ENROCOLISTIM is used orally, mixed with water for 3-5 days.

Poultry in a daily dose of 0.5 - 1.0 ml per 1 liter of drinking water or 0.1 ml per 1 kg of body weight.

Pigs, calves, lambs (up to 3 months of age), - 0.3 ml / kg of animal weight, with water for drinking in a 1:1 dilution or constantly with drinking water 0.5-0.75 ml per 1 liter of drinking water; in severe disease, the daily dose of the drug is increased to 0.5 ml / kg the mass of the animal.

With salmonellosis, mixed infections, as well as with chronic forms of animal or poultry diseases, the course of treatment is extended to 5-7 days.

During the treatment period, water with the drug should serve as the only source of drinking for birds. The medicinal solution is prepared daily in a volume designed for consumption by animals and poultry during the day.


In case of overdose in animals, violations of the gastrointestinal tract function, a decrease in feed intake are possible. In this case, it is recommended to interrupt the treatment.


Omissions should be avoided when administering the next dose of the drug, as this may lead to a decrease in effectiveness. If one dose is missed, the use of the drug is resumed at the same dose according to the same scheme.

The specifics of the drug's action during its first use or its cancellation have not been established.


Shelf life and storage conditions

ENROKOLISTIM is stored in the manufacturer's closed packaging, separately from food and feed, in a dry, light-protected place, at a temperature from 3 ° C to 25 ° C.

The shelf life of ENROKOLISTIN, subject to storage conditions in a closed package, is 2 years from the date of production, after opening the bottle - no more than 28 days.

It is forbidden to use the drug after the expiration date.

ENROCOLISTIM should be stored in places inaccessible to children.

Unused medicinal product is disposed of in accordance with the requirements of the legislation.

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