ENROCOLISTIM is a complex antimicrobial drug.
Enrofloxacin, which is part of the drug, is a derivative of quinol carboxylic acid, belongs to the 3rd generation fluoroquinolones, has a wide spectrum of bactericidal action against most gram-negative and gram-positive microorganisms, including Escherichia coli, Pseudomonas aeruginosa, Salmonella spp., Pasteurella spp., Staphylococcus spp., Staphylococcus hyicus, Streptococcu ssp., Klebsiella spp., Bordetella bronchiseptica, Campylobacter spp., Corynebacterium spp., Erysipelothrix spp., Proteus spp., Brucellacanis, Actinobacillus spp., Listeria monocytogenes, Haemophilus spp., Clostridium spp., as well as Mycoplasma spp.
Enrofloxacin suppresses bacterial DNA gyrase, disrupts DNA synthesis, bacterial growth and division; causes pronounced morphological changes (including in the cell wall and membranes), which leads to rapid bacterial cell death.
Colistin sulfate, which is part of the preparation, is polymyxin E, related to cyclic polypeptides. Colistin has a bactericidal effect on gram-negative microorganisms in the stage of division and dormancy by changing the structure and function of the outer and cytoplasmic membrane. The antibiotic is active against Escherichia coli, Salmonella spp., Pseudomonas aeruginosa, Pasteurellas pp., Haemophilus spp., Acinetobacter spp., Citrobacter spp., Klebsiella spp., Shigella spp.
When used together, enrofloxacin and colistin have a mutually reinforcing effect on microorganisms due to a different mechanism of bactericidal action. Resistance to the antibacterial components of the drug develops slowly.
After oral administration of ENROCOLISTIM, enrofloxacin is well absorbed from the gastrointestinal tract, distributed in tissues and maintained at a therapeutic level during the day. Its maximum concentration in the blood plasma is reached 1.5-3 hours after the application of the drug. Enrofloxacin is excreted through the kidneys (about 70%) and with bile (about 30%) both unchanged and in the form of metabolites, the main of which is ciprofloxacin.
Colistin sulfate is not exposed to digestive enzymes, is practically not absorbed, and has its antimicrobial effect directly in the intestine.
The combination of enrofloxacin and colistin sulfate has a potentiating effect against E.coli and P.multocida, and also prevents the rapid development of resistance of microorganisms to fluoroquinolones.