EYMESTAT 5% is an anticoccidial drug for the treatment and prevention of coccidiosis in piglets, young cattle and rabbits. Toltrazuril, which is part of the drug, is a synthetic substance that belongs to the triazintrione group, has a wide spectrum of anticoccidial action and a high degree of safety. Toltrazuril is effective against all types of parasitic coccidia, in pigs and cattle, at the stages of intracellular development of parasites, including Isospora suis, E. arloingi, Eimeria scabra, E. guevarai. E. bovis, E. zuernii, E. alabamensis, as well as eimeria rabbits E. stiedae, E.intestinalis, E.magna, E. media, E. calcicola, E. irresidua, E. perforans, E.piriformis, including strains resistant to other anticoccidial drugs.
Toltrazuril, blocking respiratory enzymes of coccidia, has a damaging effect on mitochondria and the processes of division of the coccidia nucleus, disrupting the formation of macrogametocytes. After oral administration, toltrazuril is slowly absorbed and has a coccidiocidal effect on the mucous and submucosal membranes of the gastrointestinal tract.
Toltrazuril is excreted from the body mainly unchanged, as well as in the form of metabolites (sulfones) and partially with urine.
EYMESTAT 5% by the degree of exposure to the body refers to low-hazard substances of the 4th hazard class according to GOST 12.1.007, in recommended doses does not cause side effects and complications in animals, does not interfere with the formation of immunity to coccidiosis.
The order of application:
EIMESTAT 5% is prescribed to piglets and young cattle up to 9 months of age for therapeutic and prophylactic purposes in coccidiosis.
EYMESTAT 5% is applied to piglets and young cattle up to 9 months of age orally individually once using a special dispenser in the following doses:
Before use, the suspension in the container should be thoroughly shaken In farms with coccidiosis in order to achieve maximum preventive effect and reduce the number of oocysts released into the external environment, EIMESTAT suspension of 5% should be prescribed to animals before the first clinical signs of the disease appear in the herd.
The drug is used once.
Contraindication to the use of EIMESTAT 5% is an increased individual sensitivity of the animal to the components of the drug. It is forbidden to use EIMESTAT 5% in dairy cows, due to its excretion with milk; the drug should not be used in ruminants with developed cicatricial digestion.
In case of overdose in animals, there may be a decrease in appetite, a decrease in water consumption and weight loss.
The peculiarities of the action of the drug at the first intake or at its cancellation were not revealed.