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Aerosol ANTISEPTIC STIMULATOR D-3 FRACTION for the treatment of wounds of castrated boars

16 December 2021
S. OKOLYSHEV, Doctor of Agricultural Sciences, Professor, A. KISELYOV, Doctor of Biological Sciences, Professor, MGAVMiB - MBA named after K.I. Scriabin, E. SMIRNOV, chief veterinarian, O. ZORINA, veterinarian, SEC "Mashkino".

Veterinary specialists working in pig breeding are well aware that it is many times easier to castrate boars qualitatively than to deal with various complications that often arise due to the unsuccessful execution of this operation. Therefore, the question of emerging complications and ways to prevent them is of exceptional practical interest and significance.

To date, more than 170 methods of castration of male animals are known. And at the same time, no way has yet been found that would satisfy all the requirements. Each of the existing techniques has its advantages and disadvantages both in terms of the technique of the operation, and its impact on the healing process of the wound received by the animal, its subsequent health and development.

A veterinarian should not only successfully perform castration at a high professional level, but also prevent the occurrence of any possible complications, ensure rapid and painless wound healing using both traditional and new drugs.

When castrating boars, the wound is usually not sewn up, but treated with a powder consisting of a mixture of antibiotics. Such treatment does not always lead to a positive result. Often wounds bother animals, itch and inflame, fester and bleed, which forces specialists to carry out repeated treatments. The costs of the enterprise for veterinary medicines and treatment of animals are increasing, the labor costs of specialists are increasing. At the same time, sick boars lag behind in growth and development from their peers, which undoubtedly affects the cost of production. In addition, a significant amount of powder is showered during and after wound treatment, which leads to non-production losses. The dust of antibiotics gets on the skin and into the respiratory organs of the staff.

The specialists of BIOSTIM LLC have developed and proposed an ANTISEPTIC STIMULATOR D-3 FRACTION (-3) in aerosol cans for the treatment of post-castration wounds in boars. The drug is a complex of organic and inorganic low molecular weight components, a specific combination of which provides targeted transport of active substances in the body, their free movement in the intercellular space and through cell membranes. Contained in         -3 methionine, creatinine, choline and serotonin stimulate the formation of enzymes, glutathione, other mediators and informational proteins, which leads to intensive synthesis of missing substances and their compounds in the body, normalizing the condition of animals [1, 2].

The main therapeutic property of -3 is that it is a highly effective biogenic modulator of metabolic processes and immunity [3, 4]. Aerosol cans are convenient to use, do not require additional tools and devices. When applied, the drug creates a long-lasting aseptic film on the wound that repels insects.

Table. Scheme of the experiment


Number of boars

in the group, goal.


Wound treatment method




galaxy 300 X piotren

Powder from a mixture of antibiotics







The testing of the new drug was carried out at a large pig breeding complex in the SEC "Mashkino". The aim of the experiment was to study the effect of the ANTISEPTIC STIMULANT D-3 FRACTION in the form of an aerosol on the healing of wounds of boars after removal of their testes. In this regard, the researchers were assigned the following tasks:

  • compare the rate of wound healing in animals when using ANTISEPTIC-STIMULANT aerosol D-3 FRACTION and ordinary powder from a mixture of antibiotics for prevention and treatment;
  • determine the effect of the drug on wound healing after castration;
  • to evaluate the growth of castrates before weaning from sows when treating wounds with an experimental drug and a conventional powder from a mixture of antibiotics.

Materials and methods

The studies were conducted in April 2017 according to the scheme presented in the table.

For the experiment, 60 boars were selected, from which two groups of 30 heads were formed in each - a control and an experimental one. Castration was carried out by a specialist with 10 years of experience in veterinary medicine. The sex glands of two-day-old boars were removed by an open method. In the control group of animals, wounds were treated with a powder from a mixture of antibiotics, in the experimental group with an aerosol ANTISEPTIC STIMULATOR D-3 FRACTION, spending 2-3 ml per boar. Thus, one canister of the drug with a capacity of 150 ml was enough for 50-80 treatments. At the same time, the cost of the drug per head amounted to about 2-3 rubles.

Before and after castration, the animals were kept in the same conditions corresponding to the pig breeding technology adopted on the farm. The health status of the operated boars was monitored by the same veterinary specialist who performed castration, as well as the operators serving this livestock.

Research results

The experience of using the aerosol form of the ANTISEPTIC-STIMULATOR D-3 FRACTION in the treatment of wounds of castrated boars generally gave positive results. The wounds completely healed on the third day after the operation, epithelialization was complete (photo 1). The piglets looked quite healthy, and their behavior corresponded to the physiological state of animals of this age.

In the control group, after the application of antiseptic powder, the final healing of wounds was much slower. Even on the fifth day, half of the operated animals still had visible scars with the dried drug (photo 2).

From the data obtained, it follows that the healing rate of wounds treated with aerosol ANTISEPTIC-STIMULATOR D-3 FRACTION was one and a half times higher than when using antiseptic powder. In 10% of cases, the wounds treated by him did not fully heal even five days after the operation and required additional treatment.

By weaning, the growth analysis of castrated animals showed that at the age of 29 days, the average live weight of boars in the experimental group was 6.1 kg, and their peers in the control group - 5.9 kg, which is 200 g, or 3.4% less. Consequently, after the operation, the animals treated with the ANTISEPTIC STIMULATOR D-3 FRACTION not only recovered faster, but also retained their genotypic growth energy potential. According to the results of our research, the new aerosol preparation ANTISEPTIC - STIMULATOR D-3 FRACTION is an effective alternative means of wound treatment during castration of boars in farms with intensive pork production technology.


1. Belchinskaya A.S. On the pharmacology of the drug. Scientific notes of the Vitebsk Veterinary Institute, 1958. Vol. 8.

2. Dorogov A.V. The effect of the drug         F-2 on the course of oxidative processes in the body / Derby- on 3.And. Proceedings of VNIIVSE, 1957. T.

3. Mozgov I.E. The value of biogenic stimulants in animal husbandry. Bulletin of Agricultural Science, 1956. No. 3.

4. Muchnik S.R Basic theoretical provisions on biogenic stimulants//Ukrainian conference on V.P. Filatov in animal husbandry and veterinary medicine. Abstracts of reports. Kiev, 1960.

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